This mouse is EXCELLENT for me as a lefty. I find it much more comfortable than a "neutral" mouse. I use this mouse mostly for gaming, and the responsiveness (especially for a cordless) is amazing. The button customization is nice and the "game detection" is a great feature for me.
Two minor complaints:
1.) First is the IM and E-mail notification buttons. I tend to play games in "full-screen" mode and accidentally hitting those buttons (which, due to placement, happens more often than I'd like) pulls me out of full-screen mode in whatever game I'm playing and puts the window or program it opens up in "focus" . . . so I then have to close that window, put the game back in focus, then re-enable full-screen mode: very frustrating and detrimental to game play.
I DO wish Logitech would give us the abiltiy to customize those buttons. I will NEVER use them for IMs or E-mail and they are now, to me, at BEST "wasted buttons" and at worst a hinderance to game play. It would be GREAT to have 2 more buttons on the mouse I could customize to do whatever it is I needed instead of being locked in to their current functions.
2.) Second complaint is regarding the footpads on the mouse. The glue holding them on isn't all that great and the footpads slide around and away from their original placement. The "now-exposed" glue picks up dust and dirt particles . . . making the footpads less likely to stay in place. Also, exposing the glue does have a tendency to make it harder for the mouse to "slide" on the mouse pad (or whatever surface you're mousing on).
Overall, though, I have to say, the MX610 Left-Handed Cordless Laser Mouse truly is a "godsend" for a lefty. The ergonomics alone have helped reduce pain in my hand and wrist and the functionality and customization (as all Logitech mice) are second to none. That, coupled with the ability to have a second Logitech mouse set for a right-handed person on the same computer (if only to stop any complaints from people using my computer telling me, "your mouse is broken . . .") makes it fantastic and highly practical.
I would absolutely recommend this product to anyone wanting or needing to mouse with your left hand.
Technical Expertise: Tech Savvy
I've used this product: More than a year